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Evaluation of mobile technology platform to enhance evidence based practice for the treatment & epidemiological surveillance for diarrheal diseases in Bangladesh :A cluster randomized controlled trial, Stanford University

Case fatality rates from diarrhoeal disease, including cholera, can rise above the WHO accepted threshold of 1% in both endemic and non-endemic settings, even in regions of Bangladesh. One challenge to reduce the morbidity and mortality from diarrhoeal diseases is to develop desired and scalable tools to improve decision support, and to be able to more easily report diarrhoeal cases.
We hypothesize that a mobile phone based decision support tool will improve adherence to management guidelines for fluid resuscitation compared to existing methods. Our objective is to determine if adherence to rehydration guidelines improves with the use of a mobile technology decision-support platform. To address this objective and test the hypothesis, a pilot study followed by a cluster randomized controlled trial will be conducted in the District of Netrokona, Bangladesh. The PI of this grant is, Dr. Eric Nelson, the first Global Health fellow and Instructor, who Dr. Maldonado is mentoring.



Principal Investigator:

Yvonne Maldonado

Current Research Interests: 
The research I have conducted has been focused on epidemiologic aspects of viral vaccine development and prevention of perinatal HIV transmission. A major project has been to identify the molecular epidemiology of factors affecting the immunogenicity of oral polio vaccine (OPV) among children living in developing areas of the world, where OPV immunogenicity is poor. We have identified several factors which affect the poor immunogenicity of OPV and will conduct clinical studies to attempt to improve immunogenicity. We are now working on ways to understand the transmission and circulation of...
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