Arthropod-borne viruses (arboviruses) comprise many of the most important emerging pathogens due to their geographic expansion and their increasing impact on vulnerable populations. In 2015, Zika virus (ZIKV) became the newest emerging public health threat to Latin America, with more than 14,000 cases in Salvador, Brazil, and accruing substantial evidence of resultant Guillain-Barré and microcephaly.
Project Neurodevelopment and Vector-borne Diseases: Building Research Capacity in the Tropics, Stanford (September 1, 2016 - 8/31/2018)
Vector-borne diseases (VBD) pose a significant economic and public health threat throughout developing
tropical regions worldwide, including the Caribbean. The introduction in December 2013 and rapid spread of
the chikungunya virus (CHIKV) throughout all the Caribbean nations, and more recently the emergence of the
zika virus in Suriname and Martinique highlights the need to develop regional capacity to investigate, predict,
contain, and respond to VBD.
A surveillance platform for the detection of novel pathogens and emerging infectious diseases. Currently the platform is running throughout Bangladesh and has collected hundreds of samples from high-risk acutely ill individuals. Collaboration with Stanford University, the International Centre for Diarrhoeal Disease Research, Bangladesh, and Columbia University.
Project Developing Interventions to End Cycles of Poverty Caused by Taenia solium and Neurocysticercosis, China
Neurocysticercosis is a neglected infectious disease caused by larval forms of the pig tapeworm, Taenia solium, infecting people's brains. In our exploratory work in impoverished areas of Western China focusing on disease prevalence and burden in children, we have identified widespread disease, including brain infections and resulting cognitive deficits. We hope to identify transmission pathways and pilot interventions that will reduce transmission.
Responsible for project and construction management of the $15 billion greenfield Hamad International Airport Project. Led the planning, design, construction and project management for Bechtel, with a 675 person technical team that managed a workforce which peaked at over 47,000 persons.
Led a joint venture team of Arup, Bechtel, Halcrow and Systra to deliver the £3.5 billion, 8000+ person Channel Tunnel Rail Link Section 2, a high speed rail system from Kent to Central London. The Project was comprised of 40km of tunnels, a major underground and mainline rail hub at historic St Pancras station which was meticulously refurbished, 2 new suburban stations, a new depot and major viaduct and civil works. The Project was delivered ahead of schedule and under budget for client London Continental Railways.
Led integrated client team responsible for delivering £2.9 billion in capital improvements to the Jubilee, Northern and Piccadilly lines which carry over 45% of London Underground passengers. Projects included upgrading 99 stations, 150 escalators and 32 lifts, replacing and refurbishing 150km of track; all these works delivered ahead of schedule. The largest brown-field signaling upgrade in the world, and a quantum leap from the WWII era mechanical lever-frame line-side signals being replaced, the Jubilee line upgrade increased system capacity by 40%.
We are developing methods to extract imaging features and characteristics from free text radiology reports to enable decision support.